首先，还是重申下Response Letter回复的几个基本原则：

回复审稿人意见时，要把握的几个基本原则是：1)态度和善，措辞诚恳，不要激怒审稿人；2) 回答问题时，层次要分明，抓住审稿人问题的重点，直面审稿人的问题，不要妄想着绕圈圈搪塞过去；3) 回答问题不是光嘴上说说就好，要有理有据，需要补充实验的，要用实验结果来说明，需要引用文献的，找到合适的文献进行阐述；4) 尽可能让审稿人轻松起来，所以格式很关键，不要偷懒，文章中哪些地方进行了修改，在Response letter里面要指明，并最好列出来；如果对正文或者SI里面的图表进行了修改，在response letter里面也要同步贴上去，不要将审稿人的时间浪费在帮你找文件当中；应该适当地使用粗体斜体或者下划线，帮助审稿人抓住你回答问题的重点；5) 审稿人的意见并不总是对的，所以不要别人说啥就是啥，科学原则不能违背。如果审稿人的意见有误，应该委婉地利用充实的证据来坚持自己的观点，请不要使用过激的语言。
 
重点推荐下面这种格式：

1) General response: 在逐条回复每个审稿人的意见之前，先总体回复一下，感谢编辑和审稿人对文章提出的宝贵意见，同时对response letter的格式进行简单说明，具体如下：
 
General response:We sincerely thank the editor and all reviewers for their valuable feedback that we have used to improvethe quality of our manuscript. The reviewer comments are laid out below in italicized font and specific concernshave been numbered. Our response is given in normal font and changes/additionsto the manuscript are given in blue text.
请注意：这里在格式上非常明确的一点就是：将审稿人的意见一条条编号，并用斜体标记出来，这样一目了然，审稿人可以很轻松地区分问题和回复意见；此外，对于文章中做出的标记，用不同颜色的字体标记出来，这样审稿人不需要再回到论文中去找，非常方便。这里还是重申一下这个基本原则：你替审稿人省事了，他才会让你省心！
 
2) Point-to-point response：将审稿人的意见（斜体）一条条编号，然后逐一回复（正常的字体），回复时，以Author reply或者response等字眼开头：
这里举一个例子（论文：Chem. Mater. 2015, 27, 8011-8020）
 
1. The authors suggest that a bimetallic Au-Feoxide/hydroxide forms at the electrode interface leading to enhanced OER activity. Characterization of the bimetallic system would add strength to this argument.

Response: We agree that more study would be useful to understand details of interaction and enhancement. At this point we do not have the necessary tool-set to study the structure/interaction in the proposed amorphous bimetallic (hydrated) oxide. We hope, in the future, to employ synchrotron X-ray techniques to determine the local coordination of Fe in the putative mixed Au-Fe oxide phase. This study is beyond the scope of this report which focuses on answering critical questions regarding the activity of the FeOOH phase itself. We note also that since submission of our manuscript there has been apublication by Alex Bell and Martin Head-Gordon at Berkeley showing that Fe on Au2O3 has enhanced OER activity with DFT calculations (Ref. 79). We have added this citation and reference to the manuscript.
We added to page 25-26:

We also notethat this data is consistent with the experiments and density functional theorycalculations by Klaus et. al. (published during the review process of this manuscript) that show Fe cations on the surface of Au2O3 haveenhanced OER activity relative to FeOOH.79
 
格式解析：这里所采用的格式在General response中已经做出了说明，重点就是通过字体，颜色将不同的内容区分开来，这样一目了然。还有一点值得注意的是：如果文章中添加了新的参考文献，在response里面提到的时候，应该注明"Ref. 79"等字样，提醒审稿人你已经将相关内容加入到正文中。
 
内容解析：这里之所以列出这一条回复是因为里面有很多值得关注的东西，这里一并做出解析。

重点：审稿人要求补充实验，但客观条件上不允许怎么办？

A. 首先，应该对审稿人的意见表示赞同：We agree that more study would be useful to understand details of interaction and enhancement.

B. 然后，应该对实际情况进行说明：At this point we do not have the necessary tool-set to study the structure/interaction in the proposed amorphous bimetallic (hydrated) oxide. 请注意，这里仅针对确实没有办法获得相关实验结果的情况，如果有可能，审稿人提出需要补充实验，一定按照审稿人的要求进行补充。

C. 进一步表明态度，指出哪些方法可能可以解决审稿人提出的问题，并表示后期会进行相关研究：We hope, in the future, to employ synchrotron X-ray techniques to determine the local coordination of Fe in the putative mixed Au-Fe oxide phase. This study is beyond the scope of this report which focuses on answering critical questions regarding the activity of the FeOOH phase itself.

D. 实验上暂时无法提供数据来回答审稿人的问题，就一定需要从文献中找到依据来说明：

We note also that since submission of our manuscript there has been apublication by Alex Bell and Martin Head-Gordon at Berkeley showing that Fe on Au2O3 has enhanced OER activity with DFT calculations (Ref. 79).

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